As we know, free radicals are unstable, highly oxidizing chemicals formed by cellular entities of various tissues. Increased production of these species of free radicals without proper effective functioning of the endogenous and exogenous antioxidant system creates a state of oxidative stress, potentially causing skin disorders prolonged due to functional deterioration (skin cancer, dermatitis, chronic and acute inflammatory processes), even aesthetic, with destruction of structural proteins and cellular changes with the appearance of spots, marks and other signs inherent to the internal and external skin aging process.
Using antioxidants is a way to inhibit or prevent the formation of free radicals to limit damage to the skin as well as other entities that need to be protected in the body.
Besides, antioxidants can also be considered important to maintain the stability of the formulations. The fragrance and color of a cosmetic product are decisive factors in consumer acceptance of that product. Therefore, protecting against oxidation of formulation ingredients is important, as many products have a limited shelf life due to excipients oxidizing, which can lead to aroma changes and their colors.
Many free radicals (ROS) are formed in the body, due to the formation of large amounts of hydroxyl radicals, superoxide, peroxide, singlet oxygen and hydrogen peroxide and organic substances in the skin.
Unlike superoxide, which is an oxidant that can be detoxified by the enzyme superoxide dismutase (SOD), hydroxyl radical cannot be removed by enzymatic reactions. This makes it possible to damage almost all types of large molecules: carbohydrates, nucleic acids (causing mutations), lipids (lipid peroxidation) and amino acids such as converting phenylalanine to m-tyrosine. and o-tyrosine.
Hydroxyl radicals are free radicals that cause more harmful effects in the body. Due to its extremely short half-life in living organisms. This radical can attack other molecules to capture hydrogen, reacting with compounds by adding or transferring its electrons. The formation of hydroxyl radicals is further accelerated in the presence of common antioxidants, such as vitamin C acid, vitamin E and many other phenolic antioxidants. This unintended effect raises questions about their use in skin care formulations.
Harmon also hypothesized that traces of iron and other metals would catalyze oxidation reactions in the body and that oxidative chain reactions could occur, by analogy with the principles of chemistry. study of polymers in vitro. All of these predictions have been confirmed over the past 45 years.
As the outermost organ of the body, the skin is constantly and directly exposed to oxidizing environments, including UV radiation, drugs, and air pollutants. Up to now, there is much evidence to confirm that oxidation is caused by transition metals (Fe, Cu). Sun exposure inevitably increases the levels of free iron and hydrogen peroxide within the skin, thereby promoting the formation of highly toxic hydroxyl radicals, which can take hydrogen from almost any molecule. biologically, or hydroxylate them, causing cell damage.
Phyllanthus emblica extract has high antioxidant capacity and is an excellent solution to help eliminate free hydroxyl radicals, eliminate stress on the skin, prevent skin aging, and can bring about benefits. Great value when used alone or combined with sunscreen for skin care products.
When using Phyllanthus emblica extract, it can eliminate free hydroxyl radicals to the lowest level, preventing oxidation reactions from occurring and helping to fight aging at the cellular level.
In addition to its ability to remove free hydroxyl radicals, tamarind fruit extract also shows its superior stability compared to other antioxidants such as vitamin E, vitamin C, etc.
The superior stability of tamarind fruit extract compared to commonly used antioxidants
With its strong antioxidant effect and inherent properties, Phyllanthus emblica fruit extract, in addition to its anti-aging effect on the skin, also has very good effects in:
Anti-platelet aggregation reduces the risk of blood clots, prevents strokes and strokes, and supports recovery after strokes and myocardial infarction.
Regulating blood lipid index helps enhance endothelial function, reducing the risk of cardiovascular diseases.
See details here
References:
1, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5514578/
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