GutGard (Standardized licorice extract) is effective in supporting the treatment of stomach ulcers by reducing bacterial density by up to 48%, the effect increases to 70% when used at a double dose. Reduces symptoms of discomfort caused by stomach ulcers, anti-reflux effect equivalent to Multilum-M without causing edema or hypotension.
The effects of licorice extract in supporting the treatment of gastric ulcers from traditional medicine to modern science
GutGard raw material is essentially a licorice extract (Glycyrrhiza glabra extract) standardized for high flavonoid content, containing 3.5% Glabridin and controlling glycyrrhizin content to no more than 0.5%.
Licorice has been used since ancient times as an oriental medicine with the effect of supporting digestive problems such as diarrhea, abdominal pain, expectoration, cough relief, fever reduction, anti-inflammation, detoxification, especially tetanus and diphtheria toxins. Science is increasingly developing, Licorice is researched in the form of licorice extract with intensive effects in supporting the treatment of stomach ulcers and enteritis in experimental animals. Even deeper, the GutGard ingredient is clinically proven to reduce stomach ulcers caused by Helicobacter pylori, symptoms of bloating, nausea, belching, reflux… caused by gastric ulcers and gastroesophageal reflux disease. caused by esophageal thickening.
GutGard – Standardized licorice extract helps support the treatment of stomach ulcers
In Vietnamese traditional medicine, licorice extract is used for many different uses. The effects of licorice extract are recorded in the book “Vietnamese medicinal plants and herbs” by author Do Tat Loi.
A newest effect of licorice extract discovered is its effect on gastric ulcers. At that time, scientists discovered that licorice extract had the effect of inhibiting gastric acid secretion, reducing gastric ulcers caused by increased gastric secretion. This effect was tested on anesthetized dogs.
From the results of research and practical trials compiled, author Do Tat Loi has recommended that the dosage of licorice extract to treat duodenal ulcers is 3-4g of medicinal herbs/day divided into Make 3 doses, drink continuously for 7-14 days then rest for a few days to avoid swelling and heaviness in the face.
Also in the process of research and actual treatment, oriental physicians also discovered an unwanted effect when using licorice to treat stomach ulcers: licorice extract when used for a long time will cause edema and water retention. Therefore, prescriptions to treat stomach ulcers that use licorice extract are recommended not to be used for more than 2-3 weeks.
Doctors also raise the question that swelling, facial heaviness, hypotension, and hypokalemia when using licorice extract to treat stomach ulcers are believed to be due to the active ingredient glycyrrhizin in licorice extract. . This is the premise for the manufacturer Natural Remedies to launch the ingredient GutGard – standardized licorice extract with controlled glycyrrhizin content < 0.5%.
How does the ingredient GutGard (standardized licorice extract) support the treatment of stomach ulcers?
GutGard ingredients, in addition to the advantage of not causing swelling or heaviness on the face, have also been conducted in large-scale clinical and paraclinical studies, with their effects confirmed in demanding markets such as the US. , Korea…, which must be mentioned.
The first clinical study proves: GutGard ingredients reduce unpleasant symptoms caused by stomach ulcers in the digestive tract such as bloating, flatulence, reflux, nausea… after 15 days of use.
C Standardized licorice extract (GutGard) reduces unpleasant symptoms caused by gastric ulcers
The antiemetic effect was confirmed in a preclinical study to be due to the active ingredient Glablidin contained in licorice extract. The antiemetic effect of Glabridin is equivalent to 10 mg of Domperidone (Motilium-M).
GutGard is effective in reducing nausea and reflux caused by stomach ulcers
The second clinical study proves: GutGard ingredients kill H.pylori bacteria, a type of bacteria that causes stomach ulcers and has a high risk of progressing to stomach cancer. In the study, 48% of trial participants had a reduction in H.pylori after 2 months of use.
The effect of GutGard ingredients on reducing gastric ulcers caused by H.pylori bacteria is also confirmed through a number of pre-clinical studies:
Inhibits protein synthesis, making it impossible for H.pylori bacteria to grow and replicate, leading to reduced population density in the stomach. The effect is comparable to the antibiotic Tetracycline.
Tetracyclin GutGard kills bacteria according to the mechanism of antibiotics, with an effect equivalent to 70% of Tetracycline
Inhibition of DNA gyrase reduces the replication of H.pylori bacteria, an effect comparable to the antibiotic Ciprofloxacin.
Inhibition of dihydrofolate reductase (DHFR) leads to inhibition of DNA synthesis and inhibition of cell production.
Reduces the ability of H.pylori to adhere to the gastric mucosa, reducing the possibility of gastric ulcers caused by H.pylori. A study conducted on laboratory animals also showed that GutGard was effective in reducing the appearance of gastric ulcers caused by cold stress and the drug indomethacin.
Application of standardized licorice extract (GutGard) in supporting digestion and treating gastric ulcers.
Currently, GutGard is used in many products to support digestion and treat stomach ulcers around the world. The product BCM-95™ with a combination of turmeric extract and licorice extract (GutGard) to treat heartburn and reflux has been applied and deployed on the market.
A study using GutGard ingredients in combination with Probiotics was also conducted. The results showed that GutGard is compatible with some Probiotic strains of Lactobacillus or Streptoccocus thermophilus, opening a new direction in the development of probiotic beverage products that help maintain a healthy digestive system.
GutGard ingredients are also confirmed to not inhibit digestive enzymes such as: viz. Da-amylase, a-glucosidase, phytase and xylanase, suitable as ingredients for oral products.
It can be seen that GutGard is the first plant-extracted ingredient (licorice extract) with clinical evidence to support the treatment of gastric ulcers without causing side effects such as edema, hypotension, and decreased blood pressure. blood potassium.
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Thien Nguyen is the exclusive distributor of GutGard® raw materials (standardized licorice extract) – Kills H.pylori and reduces gastric and duodenal ulcers serving the pharmaceutical and functional food manufacturing industries.
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